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Localized flexible integration of high-efficiency surface enhanced Raman scattering (SERS) monitors into microfluidic channels
Xu, BB; Ma, ZC; Wang, L; Zhang, R; Niu, LG; Yang, Z; Zhang, YL; Zheng, WH; Zhao, B; Xu, Y; Chen, QD; Xia, H; Sun, HB; Xia, H (reprint author), Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, 2699 Qianjin St, Changchun 130012, Peoples R China,hxia@jlu.edu.cn; hbsun@jlu.edu.cn
2011
Source PublicationLAB ON A CHIP
ISSN1473-0197
Volume11Issue:19Pages:3347-3351
AbstractWe report here a facile approach for flexible integration of high efficiency surface enhanced Raman scattering (SERS) monitors in a continuous microfluidic channel. In our work, femtosecond laser direct writing was adopted for highly localizable and controllable fabrication of the SERS monitor through a multi-photon absorption (MPA) induced photoreduction of silver salt solution. The silver substrate could be shaped into designed patterns, and could be precisely located at the desired position of the microchannel bed, giving the feasibility for real-time detection during reactions. SEM and TEM images show that the silver substrates were composed of crystallized silver nanoplates with an average thickness of 50 nm. AFM results reveal that the substrates were about 600 nm in height and the surface was very rough. As representative tests for SERS detection, p-aminothiophenol (p-ATP) and flavin adenine dinucleotide (FAD) were chosen as probing molecules for microfluidic analysis at visible light (514.5 nm) excitation, exhibiting an enhancement factor of similar to 10(8). In addition, the combination of the SERS substrate with the microfluidic channel allows detection of inactive analytes through in situ microfluidic reactions.
metadata_83集成光电子学国家重点实验室
KeywordMicrochip Electrophoresis Resonance Raman Single-molecule Glucose-oxidase Silver Chip Spectroscopy Nanoparticles Spectrometry Fabrication
Subject Area光电子学
Funding Organization973 Program[2011CB013005]; NSFC[60978048, 90923037]
Indexed BySCI
Language英语
Date Available2012-02-06
Document Type期刊论文
Identifierhttp://ir.semi.ac.cn/handle/172111/22875
Collection集成光电子学国家重点实验室
Corresponding AuthorXia, H (reprint author), Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, 2699 Qianjin St, Changchun 130012, Peoples R China,hxia@jlu.edu.cn; hbsun@jlu.edu.cn
Recommended Citation
GB/T 7714
Xu, BB,Ma, ZC,Wang, L,et al. Localized flexible integration of high-efficiency surface enhanced Raman scattering (SERS) monitors into microfluidic channels[J]. LAB ON A CHIP,2011,11(19):3347-3351.
APA Xu, BB.,Ma, ZC.,Wang, L.,Zhang, R.,Niu, LG.,...&hbsun@jlu.edu.cn.(2011).Localized flexible integration of high-efficiency surface enhanced Raman scattering (SERS) monitors into microfluidic channels.LAB ON A CHIP,11(19),3347-3351.
MLA Xu, BB,et al."Localized flexible integration of high-efficiency surface enhanced Raman scattering (SERS) monitors into microfluidic channels".LAB ON A CHIP 11.19(2011):3347-3351.
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