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Efficacy and reliability of long-term implantation of multi-channel microelectrode arrays in the optical nerve sheath of rabbit eyes
Wang K; Li XQ; Li XX; Pei WH; Chen HD; Dong JQ; Li, XX (reprint author), Peking Univ, Peoples Hosp, Dept Ophthalmol, 11 Xi Zhi Men Nan St, Beijing 100044, Peoples R China, drxiaoxinli@gmail.com
2011
Source PublicationVISION RESEARCH
ISSN0042-6989
Volume51Issue:17Pages:1897-1906
AbstractIn addition to epiretinal and subretinal areas, the optic nerve (ON) is also a candidate location for implanting visual prosthesis to restore vision of patients with retinitis pigmentosa (RP). Since the ON receives all the signals from the retina, stimulating the ON may potentially evoke phosphenes over a wider range of visual field. In this study, we designed a 9-channel microelectrode array and implanted it between the dura mater and pia mater of rabbit ONs by lateral orbitotomy. We recorded the current thresholds and evaluated the efficacy of the array using electrically evoked potentials (EEPs). Spatial discrimination of approximately 20 was verified by EEP maps over visual cortex. A large area of the visual field (over 130 along horizontal meridian) could be activated by this microelectrode array. Visual evoked potentials (VEPs) and different pathological examinations were used to examine potential damage of ONs. One year post implantation, we did not notice significant damages to either the ONs or the microelectrode arrays. EEPs were successfully recorded up to 6 months post implantations. However, further studies are still needed to reduce fibrous encapsulation of the microelectrode array, which resulted in a gradual elevation of current thresholds to elicit EEPs. (C) 2011 Elsevier Ltd. All rights reserved.
metadata_83集成光电子学国家重点实验室
KeywordElectrical-stimulation Retinitis-pigmentosa Evoked-potentials Artificial Vision Visual-cortex Inner Retina Prosthesis Electrode Cell Abnormalities
Subject Area光电子学
Funding OrganizationNational Basic Research Program of China[2005CB724307, 2011CB510200]; Chinese High-Tech Research and Development (863) Program[2009AA04Z326]
Indexed BySCI
Language英语
Date Available2012-02-06
Document Type期刊论文
Identifierhttp://ir.semi.ac.cn/handle/172111/22837
Collection集成光电子学国家重点实验室
Corresponding AuthorLi, XX (reprint author), Peking Univ, Peoples Hosp, Dept Ophthalmol, 11 Xi Zhi Men Nan St, Beijing 100044, Peoples R China, drxiaoxinli@gmail.com
Recommended Citation
GB/T 7714
Wang K,Li XQ,Li XX,et al. Efficacy and reliability of long-term implantation of multi-channel microelectrode arrays in the optical nerve sheath of rabbit eyes[J]. VISION RESEARCH,2011,51(17):1897-1906.
APA Wang K.,Li XQ.,Li XX.,Pei WH.,Chen HD.,...&Li, XX .(2011).Efficacy and reliability of long-term implantation of multi-channel microelectrode arrays in the optical nerve sheath of rabbit eyes.VISION RESEARCH,51(17),1897-1906.
MLA Wang K,et al."Efficacy and reliability of long-term implantation of multi-channel microelectrode arrays in the optical nerve sheath of rabbit eyes".VISION RESEARCH 51.17(2011):1897-1906.
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